Education

• Ph.D. Systems Biology, Keio University, Japan (2007-2009)

• M.S. Bioinformatics, Keio University, Japan (2005-2007)

• B.S. Environmental Information, Keio University, Japan (2001-2005)
  
  

Professional Positions

• Associate Professor, Earth-Life Science Institute/Department of Life Science and Technology, Institute of Science Tokyo, Japan  (2020-present)

• Project Associate Professor, Earth-Life Science Institute, Tokyo Institute of Technology Japan  (2017-present)

• Specially Appointed Associate Professor, Earth-Life Science Institute, Tokyo Institute of Technology Japan  (2019-2020)

• Researcher, Earth-Life Science Institute, Tokyo Institute of Technology Japan  (2018-2019)

• EON Postdoctoral Fellow, Earth-Life Science Institute, Tokyo Institute of Technology Japan  (2016-2018)

• Postdoctoral Research Fellow, UARC/NASA Ames Research Center, USA  (2013-2016)

• JSPS Postdoctoral Fellowship for Research Abroad, NASA Ames Research Center, USA  (2011-2013)

• JSPS Postdoctoral Fellow, Institute for Advanced Biosciences, Keio University, Japan (2009-2010)

Origin and evolution of enzymes involved in histidine biosynthesis pathway

ヒスチジン合成酵素の起源と進化解析

Development of sequencing techniques for peptides containing non-canonical amino acids using nanochannel-integrated nano-gap devices 

ナノギャップシーケンサーを用いた非天然型アミノ酸含有ペプチドの分析基盤の開発 

Understanding the origin of translation through reconstruction of proto-ribosome

原始リボソーム再構築による翻訳起源の解明 

Secondary structure shuffling method for exploring protein structure diversity

二次構造シャッフリング法を用いたタンパク質の構造空間の探索  

In vitro co-evolution of RNA-peptide complex

RNAタンパク質複合体の試験管内進化  

Directed evolution of CO2 fixation enzyme using protein biosensor 

バイオセンサーを用いたCO2固定酵素の指向性進化

Development of biochemical synthesis of amino acids in a cell-free system
無細胞翻訳系とアミノ酸合成系を組み合わせた反応系の構築

Understanding the non-ribosomal origin of biopolymers

非リボソーム型ポリマー合成の起源に迫る

Multiomics analysis of microorganism with a synthetic carbon fixation pathway

人工炭素固定経路を導入した微生物のマルチオミクス解析

Role of RNA modifications in the structure and function of a primordial Peptidyl Transferase Center
原始ペプチジル転移中心におけるRNA修飾の構造と機能への寄与

Evolutionary molecular engineering of the artificial nucleic acid, L-aTNA
人工核酸（L-aTNA）の進化分子工学

Phosphorylation of organic molecules using polyphosphate micro droplets
ポリリン酸微小液滴を用いた有機分子のリン酸化

Peptide interactions with prebiotic membranes

ペプチドと原始膜系の相互作用

RNA-peptide coevolution using aminoacylating ribozyme 

アミノアシル化リボザイムを用いたRNA-ペプチド共進化

Nucleotide synthesis in water/supercritical CO2 two-phase environment

超臨界CO2–水二相環境における核酸分子の合成

Chemical synthesis of proto-ribosome substrates

原始リボソームの基質の調査と化学合成

Understanding enzyme diversity by evaluating substrate interaction mode

酵素多様性の理解に向けた基質との相互作用の評価

Dessication resistance of terrestrial cyanobacterium

陸棲藍藻の乾熱耐性の調査

Analysis of the emergent sequences and fold patterns through Random oligonucleotide ligation/decomposition cycle

ランダムオリゴヌクレオチドの重合と分解から生じる配列と構造の解析

Analysis of interaction between lipid membrane and nucleic acids

脂質膜と核酸の相互作用解析

Analysis on structural diversity of phosphate-binding proteins

リン酸結合タンパク質の構造多様性の解析

Partitioning behavior and solubility of amino acids in a supercritical CO₂–water two-phase System

超臨界CO2–水二相環境におけるアミノ酸の分配挙動および溶解度の評価

Detection of RNA Modifications via Nanotechnology Platforms

ナノテクノロジープラットフォームによるRNA修飾の検出

TBD

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TBD

Understanding the sequence/structural bias at the RNA ligation junction 

RNAライゲーション部位における配列と構造バイアスの理解

TBD

TBD

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TBD

技術支援員  (東京科学大学)

研究員 （株式会社MOLCUREより出向）

研究員 (株式会社SyntheticGestaltより出向)

事務支援員

事務支援員